Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model-Reference-Cited by-同舟云学术

Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

Published:2015-03-26 Issue:13 Volume:125 Page:2111-2119
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Green Damian J.¹²^ORCID,Shadman Mazyar¹²^ORCID,Jones Jon C.¹,Frayo Shani L.¹,Kenoyer Aimee L.¹,Hylarides Mark D.¹^ORCID,Hamlin Donald K.³,Wilbur D. Scott³,Balkan Ethan R.³^ORCID,Lin Yukang¹^ORCID,Miller Brian W.⁴^ORCID,Frost Sofia H. L.¹^ORCID,Gopal Ajay K.¹²,Orozco Johnnie J.¹²^ORCID,Gooley Theodore A.¹^ORCID,Laird Kelly L.¹,Till Brian G.¹²^ORCID,Bäck Tom⁵^ORCID,Sandmaier Brenda M.¹²^ORCID,Pagel John M.¹²^ORCID,Press Oliver W.¹²^ORCID

Affiliation:

1. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

2. Departments of Medicine and

3. Radiation Oncology, University of Washington, Seattle, WA;

4. Pacific Northwest National Laboratory, Richland, WA; and

5. Department of Radiation Physics, University of Gothenberg, Gothenberg, Sweden

Abstract

Key Points α-Emitting radionuclides have the potential to overcome treatment-resistant lymphoma cell clones that evade other forms of therapy. 211At-labeled anti-CD20 monoclonal antibody eradicates lymphoma in a mouse minimal residual disease model.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/13/2111/1384387/2111.pdf

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