Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein-Reference-Cited by-同舟云学术

Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein

Published:2015-04-23 Issue:17 Volume:125 Page:2712-2719
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Vu Trang T.¹²,Zhou Ji¹³,Leslie Beverly A.¹³,Stafford Alan R.¹³,Fredenburgh James C.¹³,Ni Ran¹²,Qiao Shengjun¹³,Vaezzadeh Nima¹²,Jahnen-Dechent Willi⁴,Monia Brett P.⁵,Gross Peter L.¹²³,Weitz Jeffrey I.¹²³⁶

Affiliation:

1. Thrombosis and Atherosclerosis Research Institute,

2. Department of Medical Sciences,

3. Department of Medicine, and

4. Helmholtz-Institute for Biomedical Engineering, Biointerface Laboratory, Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) Aachen University, Aachen, Germany; and

5. Isis Pharmaceuticals, Inc., Carlsbad, CA

6. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada;

Abstract

Key Points Mice deficient in HRG have normal hemostasis, but demonstrate accelerated thrombosis via the contact system. HRG abrogates nucleic acid–driven coagulation and serves as a novel modulator of the contact system in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/17/2712/1385474/2712.pdf

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5. Contact system: a vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes.;Colman;Blood,1997

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