Suppression of in vitro megakaryopoiesis by maternal sera containing anti-HPA-1a antibodies-Reference-Cited by-同舟云学术

Suppression of in vitro megakaryopoiesis by maternal sera containing anti-HPA-1a antibodies

Published:2015-09-03 Issue:10 Volume:126 Page:1234-1236
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Liu Zhi-Jian¹,Bussel James B.²,Lakkaraja Madhavi²,Ferrer-Marin Francisca¹³,Ghevaert Cedric⁴,Feldman Henry A.⁵,McFarland Janice G.⁶,Chavda Chaitanya¹,Sola-Visner Martha¹

Affiliation:

1. Division of Newborn Medicine, Boston Children’s Hospital, Boston, MA;

2. Division of Pediatric Hematology-Oncology, New York Presbyterian Hospital, New York, NY;

3. Hematology and Medical Oncology Unit, Hospital Morales-Meseguer, Centro de Hemodonación, Instituto Murciano de Investigacion Biosanitaria, Murcia, Spain;

4. Department of Haematology, University of Cambridge/National Health Service Blood and Transplant, Cambridge, United Kingdom;

5. Clinical Research Center, Boston Children’s Hospital, Boston, MA; and

6. Platelet & Neutrophil Immunology Laboratory, Blood Center of Wisconsin, Milwaukee, WI

Abstract

Key Points Maternal sera containing anti-HPA-1a antibodies suppress in vitro megakaryopoiesis through induction of cell death. The degree of suppression of megakaryopoiesis is variable and is one of the factors determining the severity of neonatal thrombocytopenia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/10/1234/1388807/1234.pdf

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