Warfarin treatment of a patient with coagulation factor IX propeptide mutation causing warfarin hypersensitivity
Author:
Affiliation:
1. Correspondence: Søren Risom Kristensen, Department of Clinical Biochemistry and Genetics, Odense University Hospital, University of Southern Denmark, Odense, Denmark; e-mail:
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/100/7/2676/1254307/h81902002672d.pdf
Reference6 articles.
1. A mutation in the propeptide of factor IX leads to warfarin sensitivity by a novel mechanism.;Chu;J Clin Invest.,1996
2. Missense mutations at ALA-10 in the factor IX propeptide: an insignificant variant in normal life but a decisive cause of bleeding during oral anticoagulant therapy.;Oldenburg;Br J Haematol.,1997
3. Genetic predisposition to bleeding during oral anticoagulant therapy: evidence for common founder mutations (FIXVal-10 and FIX Thr-10) and an independent CpG hotspot mutation (FIXThr-10).;Oldenburg;Thromb Haemost.,2001
4. Seltene Ursache einer schweren Weichteileinblutung unter therapie mit Phenprocoumon.;Neuhaus;Dtsch Med Wochenschr.,2001
5. Thrombosis or myocardial infarction in congenital clotting factor abnormalities and chronic thrombocytopenias: a report of 21 patients and a review of 50 previously reported cases.;Goodnough;Medicine.,1983
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1. Factor IX p.A37V mutation causes severe bleeding in a patient with phenprocoumon therapy;European Journal of Medical Research;2021-06-29
2. The Conundrum of “Warfarin Hypersensitivity”;American Journal of Therapeutics;2016-05
3. Comparative genetics of warfarin resistance;Hämostaseologie;2014
4. Coagulation factor IX;its molecular structure and functional mechanism;Japanese Journal of Thrombosis and Hemostasis;2013
5. Life-threatening bleeding under vitamin K antagonists in spite of an INR in the therapeutic range;Journal of Thrombosis and Thrombolysis;2011-03-18
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