Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies-Reference-Cited by-同舟云学术

Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies

Published:2010-08-26 Issue:8 Volume:116 Page:1317-1320
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Nagel Inga¹,Szczepanowski Monika²,Martín-Subero José I.¹,Harder Lana¹,Akasaka Takashi³,Ammerpohl Ole¹,Callet-Bauchu Evelyne⁴,Gascoyne Randy D.⁵,Gesk Stefan¹,Horsman Doug⁵,Klapper Wolfram²,Majid Aneela³,Martinez-Climent José A.⁶,Stilgenbauer Stephan⁷,Tönnies Holger¹,Dyer Martin J. S.³,Siebert Reiner¹

Affiliation:

1. Institute of Human Genetics, Christian-Albrechts University Kiel & University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany;

2. Department of Pathology and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany;

3. MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom;

4. Service d'Hematologie Biologique, Centre Hospitalier Lyon Sud, Lyon, France;

5. Department of Pathology, Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC;

6. Division of Oncology, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain; and

7. Department of Internal Medicine III, University of Ulm, Ulm, Germany

Abstract

Abstract Sequence variants at the TERT-CLPTM1L locus in chromosome 5p have been recently associated with disposition for various cancers. Here we show that this locus including the gene encoding the telomerase reverse-transcriptase TERT at 5p13.33 is rarely but recurrently targeted by somatic chromosomal translocations to IGH and non-IG loci in B-cell neoplasms, including acute lymphoblastic leukemia, chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal zone lymphoma. In addition, cases with genomic amplification of TERT locus were identified. Tumors bearing chromosomal aberrations involving TERT showed higher TERT transcriptional expression and increased telomerase activity. These data suggest that deregulation of TERT gene by chromosomal abnormalities leading to increased telomerase activity might contribute to B-cell lymphomagenesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/116/8/1317/1334345/zh803410001317.pdf

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