Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing

Author:

Kurtz David M.12ORCID,Green Michael R.1ORCID,Bratman Scott V.3,Scherer Florian1,Liu Chih Long1,Kunder Christian A.4,Takahashi Kazuhiro1,Glover Cynthia1,Keane Colm5,Kihira Shingo1,Visser Brendan6,Callahan Jason7,Kong Katherine A.8,Faham Malek8,Corbelli Karen S.1,Miklos David9,Advani Ranjana H.1,Levy Ronald1,Hicks Rodney J.7,Hertzberg Mark10,Ohgami Robert S.4,Gandhi Maher K.511,Diehn Maximilian31213,Alizadeh Ash A.113ORCID

Affiliation:

1. Division of Oncology, Department of Medicine,

2. Department of Bioengineering,

3. Department of Radiation Oncology, and

4. Department of Pathology, Stanford University, Stanford, CA;

5. Princess Alexandra Hospital, Brisbane, QLD, Australia;

6. Department of Surgery, Stanford University, Stanford, CA;

7. Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, VIC, Australia;

8. Sequenta Inc., South San Francisco, CA;

9. Division of Blood and Bone Marrow Transplantation, Department of Medicine, Stanford University, Stanford, CA;

10. Department of Haematology, Westmead Hospital, Sydney, NSW, Australia;

11. Blood Cancer Research, Diamantina Institute, Translational Research Institute, University of Queensland, Queensland, QLD, Australia;

12. Institute for Stem Cell Biology and Regenerative Medicine, and

13. Stanford Cancer Institute, Stanford University, Stanford, CA

Abstract

Key Points DLBCL can be detected in the blood by immunoglobulin high-throughput sequencing (Ig-HTS) with high specificity. Although DLBCL can be detected in leukocytes or plasma by Ig-HTS, plasma has greater sensitivity and more accurately reflects disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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