Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice-Reference-Cited by-同舟云学术

Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice

Published:2016-01-21 Issue:3 Volume:127 Page:310-313
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Vasanthakumar Aparna¹,Arnovitz Stephen¹,Marquez Rafael¹,Lepore Janet¹,Rafidi George¹,Asom Anase¹,Weatherly Madison¹,Davis Elizabeth M.¹,Neistadt Barbara¹,Duszynski Robert¹,Vardiman James W.²,Le Beau Michelle M.¹³,Godley Lucy A.¹³⁴,Churpek Jane E.¹³⁴

Affiliation:

1. Section of Hematology/Oncology, Department of Medicine,

2. Department of Pathology,

3. The University of Chicago Medicine Comprehensive Cancer Center, and

4. Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL

Abstract

Key Points Brca1 deficiency causes Fanconi anemia–like cytopenias, mitomycin C hypersensitivity, and spontaneous bone marrow failure. Brca1 is critical for the maintenance of normal hematopoietic progenitor function and genomic stability in the bone marrow.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/3/310/1393648/310.pdf

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