IL-1β, in contrast to TNFα, is pivotal in blood-induced cartilage damage and is a potential target for therapy-Reference-Cited by-同舟云学术

IL-1β, in contrast to TNFα, is pivotal in blood-induced cartilage damage and is a potential target for therapy

Published:2015-11-05 Issue:19 Volume:126 Page:2239-2246
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

van Vulpen Lize F. D.¹²^ORCID,Schutgens Roger E. G.¹,Coeleveld Katja²,Alsema Els C.²,Roosendaal Goris¹,Mastbergen Simon C.²,Lafeber Floris P. J. G.²

Affiliation:

1. Van Creveldkliniek and

2. Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands

Abstract

Key Points Blood-induced joint damage is fully prevented by blocking IL-1β with a monoclonal antibody or receptor antagonist, not by TNFα blockade. IL-1β blockade prevents release of IL-6 but not TNFα from monocyte/macrophages, whereas TNFα blockade does not affect IL-1β or IL-6 release.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/19/2239/1345504/2239.pdf

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