Live cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cells-Reference-Cited by-同舟云学术

Live cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cells

Published:2015-08-20 Issue:8 Volume:126 Page:e1-e10
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Vrazo Alexandra C.¹^ORCID,Hontz Adrianne E.¹^ORCID,Figueira Sarah K.¹,Butler Braeden L.²,Ferrell Julie M.¹,Binkowski Brock F.²,Li Jinzhu¹,Risma Kimberly A.¹³

Affiliation:

1. Division of Allergy/Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH;

2. Promega Corp, Madison, WI; and

3. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH

Abstract

Key Points Natural killer cell granzyme B, A, and K delivery and subsequent caspase activation is rapid after conjugation with tumor target cells. Natural killer cells also induce caspase activation through death receptor ligation that can be monitored in real time.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/8/e1/1391737/e1.pdf

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