Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner-Reference-Cited by-同舟云学术

Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner

Published:2015-09-03 Issue:10 Volume:126 Page:1172-1183
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mochizuki-Kashio Makiko¹,Aoyama Kazumasa¹,Sashida Goro¹²,Oshima Motohiko¹,Tomioka Takahisa¹³,Muto Tomoya¹,Wang Changshan¹⁴,Iwama Atsushi¹

Affiliation:

1. Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan;

2. International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan;

3. Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan; and

4. College of Life Sciences, Inner Mongolia University, Hohhot, China

Abstract

Key Points Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous hematologic malignancies. Ezh1 is essential to maintain hematopoiesis in the setting of Ezh2 loss.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/10/1172/1389076/1172.pdf

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4. Epigenetics of hematopoietic stem cell aging and disease.;Oshima;Int J Hematol,2014

5. Ezh1 is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest.;Hidalgo;Cell Stem Cell,2012

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