A phase 2 study of idelalisib plus rituximab in treatment-naïve older patients with chronic lymphocytic leukemia

Author:

O'Brien Susan M.1,Lamanna Nicole2,Kipps Thomas J.3,Flinn Ian4,Zelenetz Andrew D.5,Burger Jan A.6,Keating Michael6,Mitra Siddhartha7,Holes Leanne8,Yu Albert S.8,Johnson David M.8,Miller Langdon L.8,Kim Yeonhee8,Dansey Roger D.8,Dubowy Ronald L.8,Coutre Steven E.7

Affiliation:

1. University of California–Irvine, Irvine Chao Family Comprehensive Cancer Center, Orange, CA;

2. Columbia University Medical Center, New York, NY;

3. University of California–San Diego, San Diego Moores Cancer Center, La Jolla, CA;

4. Sarah Cannon Research Institute, Nashville, TN;

5. Memorial Sloan-Kettering Cancer Center, New York, NY;

6. University of Texas MD Anderson Cancer Center, Houston, TX;

7. Stanford University School of Medicine, Stanford, CA; and

8. Gilead Sciences, Foster City, CA

Abstract

Key Points In 64 older patients with untreated CLL or small lymphocytic leukemia, treatment with idelalisib plus rituximab was generally well tolerated. The combination produced a very high response rate (97%), including 19% complete remission.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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