GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells

Author:

Koehn Brent H.1,Apostolova Petya2,Haverkamp Jessica M.3,Miller Jeffrey S.4,McCullar Valarie4,Tolar Jakub1ORCID,Munn David H.5,Murphy William J.6,Brickey Willie June7ORCID,Serody Jonathan S.7,Gabrilovich Dmitry I.8ORCID,Bronte Vincenzo9,Murray Peter J.3ORCID,Ting Jenny P.-Y.7,Zeiser Robert210,Blazar Bruce R.1ORCID

Affiliation:

1. Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, MN;

2. Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University, Freiburg, Germany;

3. Departments of Infectious Diseases and Immunology, St. Jude Children’s Research Hospital, Memphis, TN;

4. Blood and Marrow Transplant Program, Division of Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Minneapolis, MN;

5. Cancer Center and Department of Pediatrics, Georgia Regent’s University, Augusta, GA;

6. Departments of Dermatology and Internal Medicine, School of Medicine, University of California, Davis, Sacramento, CA;

7. Lineberger Comprehensive Cancer Center, Inflammatory Diseases Institute, Departments of Genetics and Microbiology and Immunology, University of North Carolina, Chapel Hill, NC;

8. The Wistar Institute, Philadelphia, PA;

9. Dipartimento di afferenza Medicina, Verona University, Verona, Italy; and

10. Centre for Biological Signaling Studies BIOSS, Freiburg, Germany

Abstract

Key Points MDSCs are potent suppressors of alloimmune responses; however, efficacy is limited in the context of acute GVHD due to inflammasome induction.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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