Alloantibodies to a paternally derived RBC KEL antigen lead to hemolytic disease of the fetus/newborn in a murine model-Reference-Cited by-同舟云学术

Alloantibodies to a paternally derived RBC KEL antigen lead to hemolytic disease of the fetus/newborn in a murine model

Published:2013-08-22 Issue:8 Volume:122 Page:1494-1504
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Stowell Sean R.¹,Henry Kate L.¹,Smith Nicole H.²,Hudson Krystalyn E.¹,Halverson Greg R.³,Park Jaekeun C.⁴,Bennett Ashley M.¹,Girard-Pierce Kathryn R.¹,Arthur C. Maridith¹,Bunting Silvia T.⁵,Zimring James C.⁶,Hendrickson Jeanne E.¹²

Affiliation:

1. Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, and

2. Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Division of Pediatric Hematology/Oncology, Emory University School of Medicine, Atlanta, GA;

3. New York Blood Center, New York, NY;

4. Biomedical Imaging Technology Core, Emory University and Georgia Institute of Technology, Atlanta, GA;

5. Department of Pathology, Children’s Healthcare of Atlanta, Atlanta, GA; and

6. Puget Sound Blood Center Research Institute, Seattle, WA

Abstract

Key Points Anti-KEL alloantibodies generated after exposure to paternally derived RBC antigens during pregnancy result in fetal anemia. This is the first animal model of pregnancy associated HDFN, with transfusion and pregnancy resulting in boostable anti-KEL alloantibodies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/8/1494/1374183/1494.pdf

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