Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma-Reference-Cited by-同舟云学术

Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma

Published:2013-07-11 Issue:2 Volume:122 Page:219-226
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kaiser Martin F.¹²,Johnson David C.¹,Wu Ping¹,Walker Brian A.¹,Brioli Annamaria¹³,Mirabella Fabio¹,Wardell Christopher P.¹,Melchor Lorenzo¹,Davies Faith E.¹,Morgan Gareth J.¹

Affiliation:

1. Haemato-Oncology Research Unit, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom;

2. Department of Haematology and Oncology, Charité Universitätsmedizin Berlin, Berlin, Germany; and

3. Istituto di Ematologia Seràgnoli, Università degli Studi di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy

Abstract

Key Points Epigenetic inactivation of tumor suppressor genes is associated with an unfavorable prognosis in multiple myeloma. Drug response and microenvironment interaction pathways are affected by epigenetic inactivation, linking tumor biology to prognosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/2/219/1371078/219.pdf

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4. LRpath analysis reveals common pathways dysregulated via DNA methylation across cancer types.;Kim;BMC Genomics,2012

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