Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome-Reference-Cited by-同舟云学术

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

Published:2013-07-11 Issue:2 Volume:122 Page:282-292
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Frimat Marie¹²³⁴⁵,Tabarin Fanny¹²³⁴,Dimitrov Jordan D.¹²³,Poitou Caroline²⁴,Halbwachs-Mecarelli Lise¹²³⁴,Fremeaux-Bacchi Veronique¹⁶,Roumenina Lubka T.¹²³

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale (INSERM) Unite Mixte de Recherche en Sante 872, Cordeliers Research Center, Paris, France;

2. Université Paris Descartes Sorbonne Paris-Cité, Paris, France;

3. Université Pierre et Marie Curie, Paris, France;

4. INSERM U845, Hôpital Necker, Paris, France;

5. Service de Néphrologie, Hôpital Claude Huriez, Centre Hospitalier Regional Universitaire, Lille, France; and

6. Hopital Européen Georges-Pompidou, Service d’Immunologie Biologique, Assistance Publique-Hôpitaux de Paris, Paris, France

Abstract

Key Points Heme activates complement alternative pathway in serum and on endothelial cell surfaces. Heme-induced complement activation in the presence of complement mutations contributes as a secondary hit to the development of aHUS.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/2/282/1371502/282.pdf

Reference46 articles.

1. Atypical hemolytic-uremic syndrome.;Noris;N Engl J Med,2009

2. Alternative complement pathway assessment in patients with atypical HUS.;Roumenina;J Immunol Methods,2011

3. A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function.;Roumenina;Blood,2012

4. Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations.;Fakhouri;J Am Soc Nephrol,2010

5. Heme, heme oxygenase, and ferritin: how the vascular endothelium survives (and dies) in an iron-rich environment.;Balla;Antioxid Redox Signal,2007

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