Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling

Author:

Chen Yolande1,Aardema Jorie1,Kale Sayali1,Whichard Zakary L.1,Awomolo Arinola1,Blanchard Elisabeth1,Chang Brian1,Myers David R.23,Ju Lining2,Tran Reginald23,Reece David2,Christensen Hilary4,Boukour Siham5,Debili Najet5,Strom Ted S.6,Rawlings David7,Vázquez Francisco X.8,Voth Gregory A.8,Zhu Cheng2,Kahr Walter H. A.49,Lam Wilbur A.23,Corey Seth J.1

Affiliation:

1. Departments of Pediatrics and Cell & Molecular Biology, Robert H. Lurie Comprehensive Cancer Center and Children’s Memorial Hospital, Northwestern Feinberg School of Medicine, Chicago, IL;

2. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA;

3. Department of Pediatrics, Emory University School of Medicine, Atlanta, GA;

4. Program in Cell Biology, Hospital for Sick Children, Toronto, ON, Canada;

5. Université Paris-Sud, Institut National de la Santé et de la Recherche Médicale UMR 1009, Institut Gustave Roussy, Villejuif, France;

6. Department of Pathology, VA Medical Center and the University of Tennessee School of Medicine, Memphis, TN;

7. Departments of Pediatrics and Immunology, University of Washington School of Medicine, Seattle, WA;

8. Department of Chemistry, Institute of Biophysical Dynamics, James Franck Institute, and Computation Institute, University of Chicago, Chicago, IL; and

9. Departments of Pediatrics and Biochemistry, University of Toronto, ON, Canada

Abstract

Key Points CIP4 affects the remodeling of both plasma membrane and cortical cytoskeleton in megakaryocytes. CIP4 in platelet biogenesis involves cortical tension, as does WASP, and WASP-independent plasma membrane reorganization.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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