cAMP signaling regulates platelet myosin light chain (MLC) phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway-Reference-Cited by-同舟云学术

cAMP signaling regulates platelet myosin light chain (MLC) phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway

Published:2013-11-14 Issue:20 Volume:122 Page:3533-3545
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Aburima Ahmed¹,Wraith Katie S.¹,Raslan Zaher¹,Law Robert¹,Magwenzi Simbarashe¹,Naseem Khalid M.¹

Affiliation:

1. Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull, Hull, United Kingdom

Abstract

Key Points Protein kinase A (PKA) phosphorylates RhoA on serine188 to inhibit RhoA membrane translocation and RhoA kinase (ROCK) signaling. Inhibition of RhoA/ROCK2 promotes myosin light chain (MLC) phosphatase activity, which prevents the phosphorylation of MLC and platelet shape change.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/20/3533/1372226/3533.pdf

Reference53 articles.

1. The elegant platelet: signals controlling actin assembly.;Hartwig;Thromb Haemost,1999

2. Molecular mechanisms of platelet activation.;Siess;Physiol Rev,1989

3. Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets.;Klages;J Cell Biol,1999

4. The involvement of Ca2+ and myosin light chain kinase in collagen-induced platelet activation.;Lokeshwar;Cell Biol Int Rep,1992

5. ATP augments von Willebrand factor-dependent shear-induced platelet aggregation through Ca2+-calmodulin and myosin light chain kinase activation.;Oury;J Biol Chem,2004

Cited by 91 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development of Nitric Oxide-Donating Netarsudil Derivatives as a Synergistic Therapy for Glaucoma with Reduced Ocular Irritation;Journal of Medicinal Chemistry;2024-08-20

2. Heraclenin promotes the osteogenic differentiation of bone marrow stromal cells by activating the RhoA/ROCK pathway;HISTOL HISTOPATHOL;2024

3. Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner;Cells;2024-06-26

4. Salvia miltiorrhiza ameliorates endometritis in dairy cows by relieving inflammation, energy deficiency and blood stasis;Frontiers in Pharmacology;2024-04-03

5. Activation of RhoA/ROCK2 signaling by hypoxia-inducible factor 1α in promoting tumor growth and metastasis in human colon cancer;Journal of Gastrointestinal Oncology;2024-02