G protein–dependent basal and evoked endothelial cell vWF secretion-Reference-Cited by-同舟云学术

G protein–dependent basal and evoked endothelial cell vWF secretion

Published:2014-01-16 Issue:3 Volume:123 Page:442-450
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Rusu Luiza¹,Andreeva Alexandra¹,Visintine David J.¹²,Kim Kyungho¹,Vogel Stephen M.¹,Stojanovic-Terpo Aleksandra¹,Chernaya Olga²,Liu Guoquan¹,Bakhshi Farnaz R.¹,Haberichter Sandra L.³,Iwanari Hiroko⁴,Kusano-Arai Osamu⁴,Suzuki Nobuchika⁵,Hamakubo Takao⁴,Kozasa Tohru⁵,Cho Jaehyung¹²,Du Xiaoping¹,Minshall Richard D.¹²

Affiliation:

1. Department of Pharmacology and

2. Department of Anesthesiology, University of Illinois, Chicago, IL;

3. Hemostasis Laboratory, Blood Center of Wisconsin, Medical College of Wisconsin, Milwaukee, WI; and

4. Department of Quantitative Biology and Medicine and

5. Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan

Abstract

Key Points Gα12 interaction with α-SNAP regulates basal EC vWF secretion. PAR-1 activation-dependent signaling via Gα12/RhoA and Gαq/11 enhances vWF secretion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/3/442/1377909/442.pdf

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