A distinct evolution of the T-cell repertoire categorizes treatment refractory gastrointestinal acute graft-versus-host disease

Abstract

Key Points T-cell clones identified in the GI tract of patients with steroid-refractory acute GI GVHD expand in the blood with disease progression. The T-cell repertoire in the GI tract of steroid-refractory patients at the time of diagnosis is more similar than for responsive patients.