Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors

Author:

Bots Michael1,Verbrugge Inge1,Martin Benjamin P.1,Salmon Jessica M.1,Ghisi Margherita1,Baker Adele1,Stanley Kym1,Shortt Jake1,Ossenkoppele Gert J.2,Zuber Johannes3,Rappaport Amy R.3,Atadja Peter4,Lowe Scott W.3,Johnstone Ricky W.15

Affiliation:

1. Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;

2. Department of Hematology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands;

3. Memorial Sloan Kettering Cancer Centre, New York, NY;

4. China Novartis Institutes for Biomedical Health, Shanghai, China; and

5. The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia

Abstract

Key Points HDACi-mediated differentiation therapy is a potent and molecularly rational treatment strategy in t(8;21) AML.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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