Cell-intrinsic regulation of murine dendritic cell function and survival by prereceptor amplification of glucocorticoid

Author:

Soulier Annelise1,Blois Sandra M.2,Sivakumaran Shivajanani2,Fallah-Arani Farnaz2,Henderson Stephen3,Flutter Barry2,Rabbitt Elizabeth H.4,Stewart Paul M.4,Lavery Gareth G.4,Bennett Clare2,Curnow S. John1,Chakraverty Ronjon2

Affiliation:

1. School of Immunity and Infection, Centre for Translational Inflammation Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom;

2. Transplantation Immunology Group, Department of Haematology, Cancer Institute and Institute of Immunity and Transplantation, University College London, London, United Kingdom;

3. Cancer Research UK Viral Oncology Group, University College London, London, United Kingdom; and

4. School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

Abstract

Key Points Murine dendritic cell populations are highly proficient in amplifying local glucocorticoid concentrations. This property is critical in regulating dendritic cell survival and functions in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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