Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells-Reference-Cited by-同舟云学术

Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells

Published:2013-09-19 Issue:12 Volume:122 Page:2039-2046
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Li Bin E.¹,Gan Tao¹,Meyerson Matthew²,Rabbitts Terence H.³,Ernst Patricia¹

Affiliation:

1. Department of Genetics and Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH;

2. Dana Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Department of Pathology, Boston, MA; and

3. Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom

Abstract

Key Points MLL1 does not require interaction with menin to maintain hematopoietic stem cell homeostasis. Menin and MLL1 are both critical during B-cell differentiation, but largely through distinct pathways.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/12/2039/1368866/2039.pdf

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