Long-term decline in intelligence among adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation

Author:

Krull Kevin R.1,Zhang Nan2,Santucci Aimee1,Srivastava Deo Kumar2,Krasin Matthew J.3,Kun Larry E.3,Pui Ching-Hon4,Robison Leslie L.1,Hudson Melissa M.1234,Armstrong Gregory T.1

Affiliation:

1. Department of Epidemiology and Cancer Control,

2. Department of Biostatistics,

3. Department of Radiological Sciences, and

4. Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

Abstract

Key Points Adult survivors of childhood ALL treated with cranial radiation demonstrate a decline in verbal intelligence during an interval of 28 years. This decline was associated with current attention problems, but not gender, radiation dose, or age at radiation exposure.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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