Ovariectomy expands murine short-term hemopoietic stem cell function through T cell expressed CD40L and Wnt10B

Author:

Li Jau-Yi1,Adams Jonathan1,Calvi Laura M.2,Lane Timothy F.3,Weitzmann M. Neale14,Pacifici Roberto15

Affiliation:

1. Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA;

2. Endocrine Division, Department of Medicine, University of Rochester, Rochester, NY;

3. Departments of Obstetrics and Gynecology and Biological Chemistry and Orthopedic Hospital Research Center, University of California, Los Angeles, CA;

4. Atlanta VA Medical Center, Decatur, GA; and

5. Immunology and Molecular Pathogenesis Program, Emory University, Atlanta, GA

Abstract

Key Points Ovariectomy expands short-term hemopoietic stem and progenitor cells and improves engraftment and host survival after bone marrow transplantation. T cells are required for ovariectomy to expand hemopoietic stem and progenitor cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference46 articles.

1. Role of estrogen receptor alpha in hematopoietic stem cell development and B lymphocyte maturation in the male mouse.;Thurmond;Endocrinology,2000

2. Estrogen induces thymic atrophy by eliminating early thymic progenitors and inhibiting proliferation of beta-selected thymocytes.;Zoller;J Immunol,2006

3. Estrogen loss upregulates hematopoiesis in the mouse: a mediating role of IL-6.;Jilka;Exp Hematol,1995

4. Ovariectomy augments B lymphopoiesis and generation of monocyte-macrophage precursors in rat bone marrow.;Erben;Am J Physiol,1998

5. Sex steroids and the construction and conservation of the adult skeleton.;Riggs;Endocr Rev,2002

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