Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction-Reference-Cited by-同舟云学术

Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction

Published:2018-09-13 Issue:11 Volume:132 Page:1167-1179
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Tsukiji Nagaharu¹,Inoue Osamu²,Morimoto Mitsuru³,Tatsumi Norifumi⁴,Nagatomo Hiroaki⁵,Ueta Koji⁶,Shirai Toshiaki¹,Sasaki Tomoyuki¹,Otake Shimon¹,Tamura Shogo¹,Tachibana Toshiaki⁷,Okabe Masataka⁴,Hirashima Masanori⁶,Ozaki Yukio¹,Suzuki-Inoue Katsue¹

Affiliation:

1. Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan;

2. Infection Control Office, Yamanashi University Hospital, Chuo, Yamanashi, Japan;

3. Laboratory for Lung Development, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan;

4. Department of Anatomy, The Jikei University School of Medicine, Tokyo, Japan;

5. Advanced Biotechnology Center, University of Yamanashi, Chuo, Yamanashi, Japan;

6. Division of Vascular Biology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kofu, Yamanashi, Japan; and

7. Division of Molecular Cell Biology, Core Research Facilities for Basic Science, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan

Abstract

Key Points Association of platelet Clec-2 with lymphatic podoplanin regulates lung development by facilitating alveolar duct myofibroblast differentiation. Alveolar duct myofibroblast differentiation is regulated in part by transforming growth factor-β released from platelets activated by Clec-2/podoplanin interaction.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/11/1167/1373087/blood823369.pdf

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