Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma-Reference-Cited by-同舟云学术

Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma

Published:2014-09-25 Issue:13 Volume:124 Page:2081-2090
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hoellein Alexander¹,Fallahi Mohammad²,Schoeffmann Stephanie¹,Steidle Sabine¹,Schaub Franz X.²,Rudelius Martina³,Laitinen Iina⁴,Nilsson Lisa⁵,Goga Andrei⁶,Peschel Christian¹⁷,Nilsson Jonas A.⁵,Cleveland John L.²,Keller Ulrich¹⁷

Affiliation:

1. III. Medical Department, Technische Universität München, Munich, Germany;

2. Department of Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL;

3. Institute of Pathology and Clinical Cancer Center Mainfranken, Universität Würzburg, Würzburg, Germany;

4. Department of Nuclear Medicine, Technische Universität München, Munich, Germany;

5. Department of Surgery, Sahlgrenska Cancer Center, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden;

6. Department of Cell/Tissue Biology, University of California, San Francisco, San Francisco, CA; and

7. German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany

Abstract

Key Points The Myc oncoprotein targets central regulators of the SUMOylation machinery, resulting in a hyper-SUMOylation state in Myc-induced lymphoma. Targeting SUMOylation by genetic or pharmacologic means represents a novel therapeutic option for lymphomas with MYC involvement.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/13/2081/1380196/2081.pdf

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