Elevated serum levels of IL-2R, IL-1RA, and CXCL9 are associated with a poor prognosis in follicular lymphoma

Author:

Mir Muhammad A.1,Maurer Matthew J.2ORCID,Ziesmer Steven C.1,Slager Susan L.2,Habermann Thomas1,Macon William R.3,Link Brian K.4,Syrbu Sergei4,Witzig Thomas1,Friedberg Jonathan W.5,Press Oliver6,LeBlanc Michael6,Cerhan James R.7,Novak Anne1,Ansell Stephen M.1

Affiliation:

1. Division of Hematology,

2. Biomedical Statistics and Informatics, and

3. Division of Hematopathology, Mayo Clinic, Rochester, MN;

4. College of Medicine, University of Iowa, Iowa City, IA;

5. Wilmot Cancer Institute, University of Rochester, Rochester, NY;

6. Fred Hutchinson Cancer Center/South West Oncology Group Statistical Center, Seattle, WA; and

7. Division of Epidemiology, Mayo Clinic, Rochester, MN

Abstract

Key Points Elevated IL-2R, IL-1RA, and CXCL9 are associated with shorter event-free survival in newly diagnosed FL, treated with chemoimmunotherapy. Increased serum IL-12 and IL-1RA is associated with shorter event-free survival in patients who were observed or treated with rituximab alone.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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