Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use-Reference-Cited by-同舟云学术

Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use

Published:2015-04-23 Issue:17 Volume:125 Page:2656-2664
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Telen Marilyn J.¹,Wun Ted²,McCavit Timothy L.³,De Castro Laura M.⁴,Krishnamurti Lakshmanan⁵,Lanzkron Sophie⁶,Hsu Lewis L.⁷,Smith Wally R.⁸,Rhee Seungshin⁹,Magnani John L.¹⁰,Thackray Helen¹⁰

Affiliation:

1. Department of Medicine, Division of Hematology, Duke University, Durham, NC;

2. Department of Internal Medicine, Division of Hematology/Oncology, University of California Davis Medical Center and VA Northern California Health Care System, Sacramento, CA;

3. Department of Pediatric Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX;

4. Department of Medicine, Division of Hematology and Oncology, University of Pittsburgh, Pittsburgh, PA;

5. Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA;

6. Department of Medicine, Division of Hematology, Johns Hopkins School of Medicine, Baltimore, MD;

7. Department of Pediatrics, University of Illinois, Chicago, IL;

8. Division of General Internal Medicine, Virginia Commonwealth University, Richmond, VA;

9. Rho, Inc., Chapel Hill, NC; and

10. GlycoMimetics, Inc., Gaithersburg, MD

Abstract

Key Points GMI-1070 led to statistically insignificant but large reductions in time to resolution of VOC and a significant reduction in opioid use. These results support a role for selectins in VOC and progression to a phase 3 study of GMI-1070 for SCD patients with vaso-occlusion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/17/2656/1384758/2656.pdf

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