GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia-Reference-Cited by-同舟云学术

GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia

Published:2015-01-01 Issue:1 Volume:125 Page:56-70
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ganapathi Karthik A.¹,Townsley Danielle M.²,Hsu Amy P.³,Arthur Diane C.¹,Zerbe Christa S.³,Cuellar-Rodriguez Jennifer³,Hickstein Dennis D.⁴,Rosenzweig Sergio D.⁵,Braylan Raul C.⁶,Young Neal S.²,Holland Steven M.³,Calvo Katherine R.⁶^ORCID

Affiliation:

1. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD;

2. Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD;

3. Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD;

4. Experimental Transplantation and Immunology, National Cancer Institute, National Institutes of Health, Bethesda, MD;

5. Immunology Section, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD; and

6. Hematology Section, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD

Abstract

Key Points GATA2 deficiency-associated bone marrow disorder can present with features that overlap with idiopathic aplastic anemia. GATA2 marrows have severely decreased hematogones, monocytes, NK cells, and B cells; variable dysplasia; and clonal cytogenetic abnormalities.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/1/56/1383705/56.pdf

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