Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients-Reference-Cited by-同舟云学术

Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients

Published:2014-11-06 Issue:19 Volume:124 Page:2930-2936
ISSN:0006-4971
Container-title:Blood
language:en
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Author:

Barcellini Wilma¹,Fattizzo Bruno¹,Zaninoni Anna¹,Radice Tommaso¹,Nichele Ilaria²,Di Bona Eros²,Lunghi Monia³,Tassinari Cristina⁴,Alfinito Fiorella⁵,Ferrari Antonella⁶,Leporace Anna Paola⁶,Niscola Pasquale⁷,Carpenedo Monica⁸,Boschetti Carla¹,Revelli Nicoletta⁹,Villa Maria Antonietta⁹,Consonni Dario¹⁰,Scaramucci Laura⁷,De Fabritiis Paolo⁷,Tagariello Giuseppe⁴,Gaidano Gianluca³,Rodeghiero Francesco²,Cortelezzi Agostino¹¹¹,Zanella Alberto¹

Affiliation:

1. Unità Operativa Oncoematologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy;

2. Dipartimento di Terapie Cellulari ed Ematologia, Ospedale San Bortolo, Vicenza, Italy;

3. Struttura Complessa a Direzione Universitaria Ematologia, Dipartimento di Medicina Traslazionale, Università del Piemonte Orientale Amedeo Avogadro, Novara, Italy;

4. Unità Operativa Trasfusionale e Immunologia, Centro Regionale Malattie del Sangue, Castelfranco Veneto, Italy;

5. Ematologia, Università Degli Studi di Napoli Federico II, Napoli, Italy;

6. Unità Operativa Ematologia, Ospedale Sant’Andrea, Facoltà di Medicina e Psicologia, Università “Sapienza” Roma, Roma, Italy;

7. Unità Operativa Ematologia, Ospedale S. Eugenio, Roma, Italy;

8. Unità Operativa Ematologia e Trapianto, Ospedale S. Gerardo di Monza e Università degli Studi di Milano Bicocca, Milano, Italy;

9. Unità Operativa Centro Trasfusionale e di Immunoematologia, and

10. Unità Operativa Epidemiologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; and

11. Università degli Studi di Milano, Milano, Italy

Abstract

Key Points Mixed, atypical, and warm immunoglobulin G plus C AIHA (∼30% of cases) more frequently have a severe onset (Hb ≤6 g/dL) and require multiple therapy lines. Infections, particularly after splenectomy, acute renal failure, Evans syndrome, and multitreatment, were predictors of fatal outcome.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/19/2930/1381128/2930.pdf

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4. Comparison of traditional methods and mitogen-stimulated direct antiglobulin test for detection of anti-red blood cell autoimmunity.;Barcellini;Int J Hematol,2010

5. Autoimmune hemolytic anemia.;Zanella;Haematologica,2013

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