Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial

Author:

Stilgenbauer Stephan1,Schnaiter Andrea1,Paschka Peter1,Zenz Thorsten12,Rossi Marianna3,Döhner Konstanze1,Bühler Andreas1,Böttcher Sebastian4,Ritgen Matthias4,Kneba Michael4,Winkler Dirk1,Tausch Eugen1,Hoth Patrick1,Edelmann Jennifer1,Mertens Daniel15,Bullinger Lars1,Bergmann Manuela1,Kless Sabrina1,Mack Silja1,Jäger Ulrich6,Patten Nancy7,Wu Lin7,Wenger Michael K.8,Fingerle-Rowson Günter89,Lichter Peter10,Cazzola Mario3,Wendtner Clemens M.911,Fink Anna M.9,Fischer Kirsten9,Busch Raymonde12,Hallek Michael9,Döhner Hartmut1

Affiliation:

1. Department of Internal Medicine III, Ulm University, Ulm, Germany;

2. Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, and Department of Medicine V, University of Heidelberg, Heidelberg, Germany;

3. Department of Hematology Oncology, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, University of Pavia, Italy;

4. Second Department of Medicine, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany;

5. Cooperation Unit “Mechanisms of Leukemogenesis,” German Cancer Research Center, Heidelberg, Germany;

6. Department of Hematology, Medical University of Vienna, Vienna, Austria;

7. Roche Molecular Systems, Pleasanton, CA;

8. Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland;

9. Department of Internal Medicine I, University Hospital Cologne, Cologne, Germany;

10. Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany;

11. Department I of Internal Medicine, Klinikum Schwabing, Munich, Germany; and

12. Institute for Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany

Abstract

Key Points Independent prognostic impact of biological markers, notably TP53 and SF3B1 mutations, in CLL patients requiring therapy. NOTCH1 mutation as a predictive factor for reduced benefit from the addition of rituximab to FC chemotherapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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