Spontaneous heparin-induced thrombocytopenia syndrome: 2 new cases and a proposal for defining this disorder-Reference-Cited by-同舟云学术

Spontaneous heparin-induced thrombocytopenia syndrome: 2 new cases and a proposal for defining this disorder

Published:2014-06-05 Issue:23 Volume:123 Page:3651-3654
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Warkentin Theodore E.¹,Basciano Paul A.²,Knopman Jared³,Bernstein Richard A.⁴

Affiliation:

1. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada;

2. Department of Medicine, and

3. Division of Interventional Neuroradiology, Department of Neurosurgery, Weill Cornell Medical Center, New York, NY; and

4. Ken and Ruth Davee Department of Neurology and Clinical Neurological Sciences, Feinberg School of Medicine of Northwestern University, Chicago, IL

Abstract

Key Points Two well-documented cases of a HIT-mimicking disorder without proximate heparin exposure (spontaneous HIT syndrome) are reported. The definition of spontaneous HIT syndrome should include strong serum-induced platelet activation at 0 IU/mL heparin (inhibited at 100 IU/mL).

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/23/3651/1377566/3651.pdf

Reference22 articles.

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3. Delayed-onset heparin-induced thrombocytopenia and thrombosis.;Warkentin;Ann Intern Med,2001

4. A spontaneous prothrombotic disorder resembling heparin-induced thrombocytopenia.;Warkentin;Am J Med,2008

5. Fatal heparin-induced thrombocytopenia (HIT) during warfarin thromboprophylaxis following orthopedic surgery: another example of ‘spontaneous’ HIT?;Jay;J Thromb Haemost,2008

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