IKK-dependent activation of NF-κB contributes to myeloid and lymphoid leukemogenesis by BCR-ABL1-Reference-Cited by-同舟云学术

IKK-dependent activation of NF-κB contributes to myeloid and lymphoid leukemogenesis by BCR-ABL1

Published:2014-04-10 Issue:15 Volume:123 Page:2401-2411
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hsieh Mo-Ying¹²,Van Etten Richard A.¹³

Affiliation:

1. Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA;

2. Program in Molecular and Cellular Physiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA; and

3. Division of Hematology/Oncology, Tufts Medical Center, Boston, MA

Abstract

Key Points Inhibitors of NF-κB activation attenuate lymphoid and myeloid leukemogenesis by BCR-ABL1 and decrease leukemic stem cells in vivo. These results validate IKKs and NF-κB signaling as pharmacological targets for therapy of CML and Ph+ B-ALL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/15/2401/1375688/2401.pdf

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