UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity-Reference-Cited by-同舟云学术

UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity

Published:2014-10-09 Issue:15 Volume:124 Page:2362-2369
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bordeleau Marie-Eve¹,Aucagne Romain¹,Chagraoui Jalila¹,Girard Simon¹,Mayotte Nadine¹,Bonneil Éric¹,Thibault Pierre¹²,Pabst Caroline¹,Bergeron Anne³,Barabé Frédéric³⁴,Hébert Josée⁵,Sauvageau Martin¹,Boutonnet Christel¹,Meloche Sylvain¹⁶,Sauvageau Guy¹⁵⁷

Affiliation:

1. Institute for Research in Immunology and Cancer and

2. Departments of Biochemistry and Chemistry, Université de Montréal, Montréal, QC, Canada;

3. Centre Hospitalier Universitaire de Québec, Centre de Recherche du Centre Hospitalier de l’Université Laval and Hôpital de l’Enfant-Jésus, Quebec City, QC, Canada;

4. Department of Medicine, Université Laval, Quebec City, QC, Canada;

5. Division of Hematology and Leukemia Cell Bank of Quebec, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada; and

6. Department of Pharmacology and

7. Department of Medicine, Université de Montréal, Montréal, QC, Canada

Abstract

Key Points UBAP2L interacts with BMI1 as part of a novel Polycomb subcomplex. UBAP2L regulates HSC activity via a mechanism unrelated to the repression of the Ink4a/Arf locus.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/15/2362/1380825/2362.pdf

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4. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.;Jacobs;Nature,1999

5. Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1.;Iwama;Immunity,2004

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