Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans-Reference-Cited by-同舟云学术

Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans

Published:2013-04-18 Issue:16 Volume:121 Page:3117-3125
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kuehn Hye Sun¹,Niemela Julie E.¹,Rangel-Santos Andreia¹,Zhang Mingchang¹,Pittaluga Stefania²,Stoddard Jennifer L.¹,Hussey Ashleigh A.³,Evbuomwan Moses O.²,Priel Debra A. Long⁴,Kuhns Douglas B.⁴,Park C. Lucy⁵,Fleisher Thomas A.¹,Uzel Gulbu³,Oliveira João B.¹

Affiliation:

1. Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD;

2. Laboratory of Pathology, National Cancer Institute, and

3. Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD;

4. Clinical Services Program, SAIC–Frederick, Inc, NCI–Frederick, Frederick, MD; and

5. Division of Pediatric Allergy and Immunology and Pulmonology, Children’s Hospital of the University of Illinois, Chicago, IL

Abstract

Key Points Mutations in PRKCD cause a syndrome characterized by chronic benign lymphadenopathy, positive autoantibodies, and NK dysfunction. PRKCD deficiency disrupts control of B-cell proliferation and apoptosis and affects NK-cell cytolytic activity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/16/3117/1330273/3117.pdf

Reference20 articles.

1. Inositol trisphosphate, a novel second messenger in cellular signal transduction.;Berridge;Nature,1984

2. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.;Nishizuka;Science,1992

3. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta.;Miyamoto;Nature,2002

4. Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta.;Fujii;J Biol Chem,2000

5. Protein kinase C family functions in B-cell activation.;Guo;Curr Opin Immunol,2004

Cited by 126 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cleavage of protein kinase c δ by caspase-3 mediates proinflammatory cytokine-induced apoptosis in pancreatic islets;Journal of Biological Chemistry;2024-09

2. PKCδ Protects against Lupus Autoimmunity;Biomedicines;2024-06-19

3. Si algo puede fallar, fallará: el virus Epstein-Barr y su contención inmunitaria;Revista Alergia México;2024-04-23

4. Mendelian Causes of Autoimmunity: the Lupus Phenotype;Journal of Clinical Immunology;2024-04-15

5. Vasculitis and vasculopathy associated with inborn errors of immunity: an overview;Frontiers in Pediatrics;2024-01-31