Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody-Reference-Cited by-同舟云学术

Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody

Published:2013-04-04 Issue:14 Volume:121 Page:2804-2813
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yoshikawa Mai¹,Mukai Yohei¹²,Okada Yoshiaki¹,Tsumori Yuki¹,Tsunoda Shin-ichi²,Tsutsumi Yasuo¹²,Aird William C.³,Yoshioka Yasuo¹,Okada Naoki¹,Doi Takefumi¹,Nakagawa Shinsaku¹

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan

2. Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation (NiBio), Osaka, Japan

3. Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA

Abstract

Key PointsFirst therapeutic application that targets Robo4 on the tumor blood vasculature High-throughput screening system to isolate cell-internalizing monoclonal antibodies useful to develop effective antibody-drug conjugates

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/14/2804/1364846/2804.pdf

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5. Antibody drug-conjugates targeting the tumor vasculature: Current and future developments.;Gerber;MAbs,2009

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