Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice-Reference-Cited by-同舟云学术

Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice

Published:2015-04-16 Issue:16 Volume:125 Page:2558-2567
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hijazi Nuha¹,Abu Fanne Rami¹,Abramovitch Rinat²,Yarovoi Serge³,Higazi Muhamed¹,Abdeen Suhair¹,Basheer Maamon¹,Maraga Emad¹,Cines Douglas B.³,Al-Roof Higazi Abd¹³

Affiliation:

1. Department of Clinical Biochemistry and

2. MRI/MRS Laboratory of the Human Biology Research Center, Department of Medical Biophysics, Hebrew University-Hadassah Medical Center, Jerusalem, Israel; and

3. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Abstract

Key Points Closed head trauma sequentially releases tPA followed by uPA from injured brain. Increased uPA is responsible for delayed intracerebral hemorrhage, which is prevented by a tPA variant that inhibits uPA activity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/16/2558/1384721/2558.pdf

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