Role of LRF/Pokemon in lineage fate decisions-Reference-Cited by-同舟云学术

Role of LRF/Pokemon in lineage fate decisions

Published:2013-04-11 Issue:15 Volume:121 Page:2845-2853
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lunardi Andrea¹,Guarnerio Jlenia¹,Wang Guocan¹,Maeda Takahiro²,Pandolfi Pier Paolo¹

Affiliation:

1. Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center; and

2. Division of Hematopoietic Stem Cell and Leukemia Research, Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA.

Abstract

AbstractIn the human genome, 43 different genes are found that encode proteins belonging to the family of the POK (poxvirus and zinc finger and Krüppel)/ZBTB (zinc finger and broad complex, tramtrack, and bric à brac) factors. Generally considered transcriptional repressors, several of these genes play fundamental roles in cell lineage fate decision in various tissues, programming specific tasks throughout the life of the organism. Here, we focus on functions of leukemia/lymphoma-related factor/POK erythroid myeloid ontogenic factor, which is probably one of the most exciting and yet enigmatic members of the POK/ZBTB family.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/15/2845/1365472/2845.pdf

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