Interferon-free antiviral treatment in B-cell lymphoproliferative disorders associated with hepatitis C virus infection

Author:

Arcaini Luca12ORCID,Besson Caroline3ORCID,Frigeni Marco1ORCID,Fontaine Hélène4ORCID,Goldaniga Maria5,Casato Milvia6ORCID,Visentini Marcella6ORCID,Torres Harrys A.7ORCID,Loustaud-Ratti Veronique8ORCID,Peveling-Oberhag Jan9,Fabris Paolo10,Rossotti Roberto11ORCID,Zaja Francesco12ORCID,Rigacci Luigi13,Rattotti Sara2ORCID,Bruno Raffaele1415ORCID,Merli Michele16ORCID,Dorival Céline17,Alric Laurent18ORCID,Jaccard Arnaud8,Pol Stanislas4ORCID,Carrat Fabrice1719ORCID,Ferretti Virginia Valeria1ORCID,Visco Carlo20ORCID,Hermine Olivier2122

Affiliation:

1. Department of Molecular Medicine, University of Pavia, Pavia, Italy;

2. Department of Hematology Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy;

3. Assistance Publique–Hôpitaux de Paris Centre Hospitalier Universitaire Bicêtre, Université Paris Sud, INSERM, Le Kremlin-Bicêtre, France;

4. Paris 5 Descartes University, INSERM U1213 and Unité mixte de service 20, Institut Pasteur, Department of Hepatology, Hôpital Cochin, Assistance Publique–Hôpitaux de Paris, Paris, France;

5. Department of Hematology, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy;

6. Division of Clinical Immunology, Sapienza University of Rome, Fondazione Roma, Rome, Italy;

7. Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX;

8. Department of Hepatology, Centre Hospitalier Universitaire Limoges, U850 INSERM, University of Limoges, Limoges, France;

9. Department of Internal Medicine 1, Goethe University Hospital, Frankfurt, Germany;

10. Division of Infectious Diseases, Ospedale San Bortolo, Vicenza, Italy;

11. Department of Infectious Diseases, Ospedale Niguarda Ca’ Granda, Milan, Italy;

12. Hematology Unit, Centro Trapianti e Terapie Cellulari Carlo Melzi, Dipartimento di Scienze Mediche Sperimentali e Cliniche, Azienda Sanitaria Universitaria Integrata, Udine, Italy;

13. Department of Hematology Azienda Ospedaliero-Universitaria Careggi, Florence, Italy;

14. Department of Clinical Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy;

15. Division of Infectious and Tropical Diseases, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy;

16. Division of Hematology, Ospedale di Circolo e Fondazione Macchi, University of Insubria, Varese, Italy;

17. Sorbonne Universités, Pierre and Marie Curie University (University of Paris 06), INSERM, Institut Pierre Louis d’épidémiologie et de Santé Publique (Unité mixte de recherche S1136), Paris, France;

18. Toulouse 3 University, Unité mixte de recherche 152 Institut de Recherche pour le Développement, Department of Internal Medicine and Digestive Diseases, Hôpital Purpan, Toulouse, France;

19. Public Health Department, Assistance Publique–Hôpitaux de Paris, Paris, France;

20. Department of Cell Therapy and Hematology, Ospedale San Bortolo, Vicenza, Italy;

21. Paris 5 Descartes University, Assistance Publique–Hôpitaux de Paris, Department of Adult Hematology and Imagine Institute, Hôpital Necker, Paris, France; and

22. INSERM U1163, Centre National de la Recherche Scientifique Équipes de recherche labellisées 8254, Université Sorbonne Paris Cité, Imagine Institute, Paris, France

Abstract

Key Points Direct-acting antiviral agents are able to induce lymphoma response in patients with HCV-associated indolent non-Hodgkin lymphoma. The highest rate of lymphoma response (73%) was observed in patients with marginal zone lymphoma.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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