PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study

Author:

Bruzelius Maria12,Iglesias Maria Jesus3ORCID,Hong Mun-Gwan3ORCID,Sanchez-Rivera Laura3,Gyorgy Beata4,Souto Juan Carlos5,Frånberg Mattias26,Fredolini Claudia3ORCID,Strawbridge Rona J.2ORCID,Holmström Margareta12,Hamsten Anders2ORCID,Uhlén Mathias3,Silveira Angela2ORCID,Soria Jose Manuel7,Smadja David M.8910ORCID,Butler Lynn M.1112ORCID,Schwenk Jochen M.3ORCID,Morange Pierre-Emmanuel1314ORCID,Trégouët David-Alexandre415,Odeberg Jacob123ORCID

Affiliation:

1. Coagulation Unit, Hematology Centre, Karolinska University Hospital, Stockholm, Sweden;

2. Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden;

3. Department of Proteomics, School of Biotechnology, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden;

4. Institute of Cardiometabolism and Nutrition Institute for Cardiometabolism and Nutrition, Paris, France;

5. Unitat d'Hemostàsia i Trombosi, IIB-Sant Pau, Barcelona, Spain;

6. Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden;

7. Unitat de Genòmica de Malalties Complexes, IIB-Sant Pau, Barcelona, Spain;

8. Sorbonne Paris Cité, Université Paris Descartes, Paris, France;

9. INSERM UMR-S1140, Faculté de Pharmacie de Paris, Paris, France;

10. l'Assistance Publique-Hôpitaux de Paris, Service d’Hématologie Biologique, Hôpital Européen Georges Pompidou, Paris, France;

11. Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;

12. Institute for Clinical Chemistry and Laboratory Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany;

13. Aix-Marseille University, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, Marseille, France;

14. Laboratory of Hematology, La Timone Hospital, Marseille, France; and

15. Sorbonne Universités, Pierre and Marie Curie University University of Paris 06, INSERM, UMR_S 1166, Team Genomics and Pathophysiology of Cardiovascular Diseases, Paris, France

Abstract

Key Points High-throughput affinity plasma proteomic profiling can identify candidate plasma biomarkers for VTE. Elevated plasma PDGFB levels are identified as associated with VTE in 2 independent case control studies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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