Establishing human leukemia xenograft mouse models by implanting human bone marrow–like scaffold-based niches-Reference-Cited by-同舟云学术

Establishing human leukemia xenograft mouse models by implanting human bone marrow–like scaffold-based niches

Published:2016-12-22 Issue:25 Volume:128 Page:2949-2959
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Antonelli Antonella¹^ORCID,Noort Willy A.²,Jaques Jenny¹,de Boer Bauke¹,de Jong-Korlaar Regina²,Brouwers-Vos Annet Z.¹,Lubbers-Aalders Linda²,van Velzen Jeroen F.³,Bloem Andries C.³,Yuan Huipin⁴,de Bruijn Joost D.⁵,Ossenkoppele Gert J.²,Martens Anton C. M.²,Vellenga Edo¹,Groen Richard W. J.²,Schuringa Jan Jacob¹

Affiliation:

1. Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, The Netherlands;

2. Department of Hematology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands;

3. Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands;

4. Xpand Biotechnology BV, Bilthoven, The Netherlands; and

5. Queen Mary University of London, School of Engineering and Materials Science, London, United Kingdom

Abstract

Key Points Humanized niche xenograft mouse models were generated that enabled engraftment of patients’ leukemia cells covering all risk groups. Self-renewal was better maintained in the humanized niches as determined by serial transplantation and genome-wide transcriptome studies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/25/2949/1397201/blood719021.pdf

Reference35 articles.

1. Modeling the initiation and progression of human acute leukemia in mice;Barabé;Science,2007

2. MLL-AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny;Horton;Leukemia,2013

3. BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells;Rizo;Blood,2010

4. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia;Wei;Cancer Cell,2008

5. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice;Townsend;Cancer Cell,2016

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