Matching for the nonconventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD-Reference-Cited by-同舟云学术

Matching for the nonconventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD

Published:2016-10-13 Issue:15 Volume:128 Page:1979-1986
ISSN:0006-4971
Container-title:Blood
language:en
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Author:

Carapito Raphael¹²³⁴,Jung Nicolas¹²³,Kwemou Marius¹²³,Untrau Meiggie¹²³,Michel Sandra¹²³⁴,Pichot Angélique¹²³,Giacometti Gaëlle²⁵,Macquin Cécile¹²³,Ilias Wassila¹²³,Morlon Aurore²⁵,Kotova Irina²⁵,Apostolova Petya⁶,Schmitt-Graeff Annette⁷,Cesbron Anne²⁸⁹¹⁰,Gagne Katia²⁸¹¹,Oudshoorn Machteld¹²¹³,van der Holt Bronno¹⁴,Labalette Myriam¹⁵¹⁶,Spierings Eric¹⁷,Picard Christophe¹⁸,Loiseau Pascale²⁹¹⁹,Tamouza Ryad²¹⁹,Toubert Antoine²⁹¹⁹,Parissiadis Anne⁹²⁰,Dubois Valérie²¹,Lafarge Xavier²²,Maumy-Bertrand Myriam²³,Bertrand Frédéric²³,Vago Luca²⁴²⁵,Ciceri Fabio²⁴,Paillard Catherine¹²⁹²⁶,Querol Sergi²⁷,Sierra Jorge²⁸,Fleischhauer Katharina²⁹,Nagler Arnon³⁰,Labopin Myriam³¹,Inoko Hidetoshi³³²,von dem Borne Peter A.³³,Kuball Jürgen³⁴,Ota Masao³³²,Katsuyama Yoshihiko³³⁵,Michallet Mauricette⁹³⁶,Lioure Bruno⁹³⁷,Peffault de Latour Régis²⁹³⁸,Blaise Didier⁹³⁹,Cornelissen Jan J.⁴⁰,Yakoub-Agha Ibrahim⁹¹⁶,Claas Frans¹³,Moreau Philippe⁹⁴¹,Milpied Noël⁹⁴²,Charron Dominique²¹⁹,Mohty Mohamad⁹³¹⁴³⁴⁴,Zeiser Robert⁶,Socié Gérard²⁹³⁸,Bahram Seiamak¹²³⁴

Affiliation:

1. Laboratoire d’ImmunoRhumatologie Moléculaire, INSERM Unité Mixte de Recherche (UMR)_S1109, Plateforme GENOMAX, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg, and

2. LabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France;

3. INSERM Franco-Japanese Nextgen HLA laboratory, Nagano, Japan and Strasbourg, France;

4. Laboratoire d’Immunologie, Plateau Technique de Biologie, Pôle de Biologie, Nouvel Hôpital Civil, Strasbourg, France;

5. BIOMICA SAS, Strasbourg, France;

6. Department of Hematology and Oncology, Freiburg University Medical Center, Centre for Biological Signalling Studies BIOSS, Albert Ludwigs University, Freiburg, Germany;

7. Institute of Pathology, University Hospital, Freiburg, Germany;

8. Etablissement Français du Sang (EFS) Pays de la Loire, Laboratoire HLA, Nantes, France;

9. Société Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France;

10. Société Francophone d'Histocompatibilité et d'Immunogénétique, Paris, France;

11. Laboratoire EA4271 “Immunovirologie et Polymorphisme Génétique,” Nantes, France;

12. Europdonor, Matchis Foundation, Leiden, The Netherlands;

13. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands;

14. Haemato Oncology Foundation for Adults in the Netherlands Data Center, Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands;

15. Laboratoire d'Immunologie, Centre Hospitalier Régional Universitaire de Lille, Lille, France;

16. Lille Inflammation Research International Center INSERM U995, Université Lille 2, Lille, France;

17. Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands;

18. Aix-Marseille Université, Centre National de la Recherche Scientifique (CNRS), EFS, Anthropologie bio-culturelle, Droit, Éthique & Santé UMR 7268, Marseille, France;

19. Laboratoire Jean Dausset, INSERM UMR_S 1160, Hôpital Saint-Louis, Paris, France;

20. EFS Alsace Lorraine Champagne Ardenne, Laboratoire HLA, Strasbourg, France;

21. EFS Rhône-Alpes, Laboratoire HLA, Lyon, France;

22. EFS Aquitaine Limousin, Laboratoire HLA, Bordeaux, France;

23. Institut de Recherche Mathématique Avancée, CNRS UMR 7501, LabEx Institut de Recherche en Mathématiques, ses Interactions et Applications, Université de Strasbourg, Strasbourg, France;

24. Hematology and Bone Marrow Transplantation Unit, and

25. Unit of Immunogenetics, Leukemia Genomics, and Immunobiology, IRCCS San Raffaele Scientific Institute, Milan, Italy;

26. Service d'Hématologie et d’Oncologie pédiatrique, Hôpitaux Universitaires de Strasbourg, Strasbourg, France;

27. Barcelona Cord Blood Bank, Barcelona, Spain;

28. Hematology Department, Hospital de la Santa Creu I Sant Pau, IIB Sant Pau and Josep Carreras Leukemia Research Institute, Universitat Autònoma de Barcelona, Red de Càncer, Barcelona, Spain;

29. Institute of Experimental Cellular Therapy, Essen University Hospital, Essen, Germany;

30. Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Israel;

31. Département d'Hématologie, Hôpital Saint Antoine, Paris, France;

32. Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan;

33. Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands;

34. Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands;

35. Department of Pharmacy, Shinshu University Hospital, Matsumoto, Japan;

36. Centre Hospitalier Lyon Sud, Hématologie 1G, Hospices Civils de Lyon, Pierre Bénite, Lyon, France;

37. Service d’Hématologie Adulte, Hôpitaux Universitaires de Strasbourg, Strasbourg, France;

38. Service d’Hématologie–Greffe, Hôpital Saint-Louis, Assistance Publique–Hôpitaux de Paris, Paris, France;

39. Institut Paoli Calmettes, Marseille, France;

40. Department of Hematology and Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands;

41. Service d'Hématologie Clinique, CHU Hôtel Dieu, Nantes, France;

42. Service d'Hématologie et de Thérapie Cellulaire, CHU Haut-Lévêque, Bordeaux, France;

43. Université Pierre & Marie Curie, Paris, France; and

44. Centre de Recherche Saint-Antoine, INSERM UMR_S 938, Paris, France

Abstract

Key Points Matching for MICA significantly reduces the incidence of acute and chronic GVHD in otherwise HLA 10/10-matched unrelated-donor HCT. Our results formally define MICA as a novel major histocompatibility complex-encoded human transplantation antigen.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/15/1979/1396040/1979.pdf

Reference49 articles.

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