Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia

Author:

Elena Chiara12,Gallì Anna2,Such Esperanza3,Meggendorfer Manja4,Germing Ulrich5,Rizzo Ettore6,Cervera Jose3,Molteni Elisabetta1,Fasan Annette4,Schuler Esther5,Ambaglio Ilaria2,Lopez-Pavia Maria3,Zibellini Silvia2,Kuendgen Andrea5,Travaglino Erica2,Sancho-Tello Reyes7,Catricalà Silvia2,Vicente Ana I.8,Haferlach Torsten4,Haferlach Claudia4,Sanz Guillermo F.3,Malcovati Luca12,Cazzola Mario12

Affiliation:

1. Department of Molecular Medicine, University of Pavia, Pavia, Italy;

2. Department of Hematology Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Policlinico San Matteo, Pavia, Italy;

3. Department of Hematology, Hospital Universitario y Politecnico La Fe, Valencia, Spain;

4. Munich Leukemia Laboratory GmbH, Munich, Germany;

5. Department of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, Düsseldorf, Germany;

6. Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy;

7. Department of Hematology, Hospital Arnau de Vilanova, Valencia, Spain; and

8. Department of Hematology, Hospital de La Ribera, Alzira, Spain

Abstract

Key Points Risk assessment is crucial in patients with CMML because survival may range from a few months to several years. Integrating clinical features, morphology, and genetic lesions significantly improves risk stratification in CMML.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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4. Chronic myelomonocytic leukaemia.;Vardiman,2008

5. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.;Arber;Blood,2016

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