Matching for the MICA-129 polymorphism is beneficial in unrelated hematopoietic stem cell transplantation

Author:

Fuerst Daniel12,Neuchel Christine12,Niederwieser Dietger3,Bunjes Donald4,Gramatzki Martin5,Wagner Eva6,Wulf Gerald7,Glass Bertram8,Pfreundschuh Michael9,Einsele Hermann10,Arnold Renate11,Stuhler Gernot12,Schaefer-Eckart Kerstin13,Freitag Sebastian14,Casper Jochen15,Kaufmann Martin16,Wattad Mohammed17,Hertenstein Bernd18,Klein Stefan19,Ringhoffer Mark20,Mytilineos Daphne2,Tsamadou Chrysanthi12,Mueller Carlheinz2122,Schrezenmeier Hubert12,Mytilineos Joannis1222

Affiliation:

1. Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden Wuerttemberg-Hessen, Ulm, and University Hospital Ulm, Ulm, Germany;

2. Institute of Transfusion Medicine, University of Ulm, Ulm, Germany;

3. Department of Hematology/Oncology, University of Leipzig, Leipzig, Germany;

4. Department of Internal Medicine III, University of Ulm, Ulm, Germany;

5. Division of Stem Cell Transplantation and Immunotherapy, 2nd Department of Medicine, University of Kiel, Kiel, Germany;

6. Department of Medicine III, Johannes Gutenberg-University Mainz, Mainz, Germany;

7. Department of Hematology/Oncology, Georg-August-University Göttingen, Göttingen, Germany;

8. Department of Hematology/Oncology, Asklepios Klinik St. Georg Hamburg, Hamburg, Germany;

9. Department Internal Medicine I, Universitätsklinikum des Saarlandes, Homburg, Germany;

10. Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany;

11. Hematology/Oncology Department, Charité Campus Virchow Berlin, Berlin, Germany;

12. Centre for Bone Marrow and Blood Stem Cell Transplantation, Deutsche Klinik für Diagnostik, Wiesbaden, Germany;

13. Medical Clinic 5: Hematology, Oncology, Nuremberg Hospital, Nuremberg, Germany;

14. Department of Medicine III, Hematology/Oncology/Palliative Care, Rostock University Medical Center, Rostock, Germany;

15. Division of Hematology and Oncology, Oldenburg Clinic, University of Rostock, Oldenburg, Germany;

16. 2nd Department of Internal Medicine, Oncology and Hematology, Robert Bosch Hospital Stuttgart, Stuttgart, Germany;

17. Hematology/Oncology, Evangelic Clinic Essen-Werden, Essen-Werden, Germany;

18. Hematology/Oncology, Klinikum Bremen-Mitte, Bremen, Germany;

19. Universitätsmedizin Mannheim, Med. Klinik III, Mannheim, Germany;

20. Medizinische Klinik III, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany;

21. Zentrales Knochenmarkspender-Register für Deutschland, German National Bone Marrow Donor Registry, Ulm, Germany; and

22. German Registry for Stem Cell Transplantation, Ulm, Germany

Abstract

Key Points MICA-129 matching improves survival in uHSCT. MICA-129 mismatches were observed in 6.7% of all transplant patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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