Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells-Reference-Cited by-同舟云学术

Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells

Published:2016-09-22 Issue:12 Volume:128 Page:e32-e42
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Reisz Julie A.¹,Wither Matthew J.¹,Dzieciatkowska Monika¹,Nemkov Travis¹,Issaian Aaron¹,Yoshida Tatsuro²,Dunham Andrew J.²,Hill Ryan C.¹,Hansen Kirk C.¹,D’Alessandro Angelo¹

Affiliation:

1. Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO; and

2. New Health Sciences Inc, Boston, MA

Abstract

Key Points Reversible oxidation of GAPDH promotes metabolic reprogramming of stored RBCs, as gleaned through tracing with 13C1,2,3-glucose. Storage-induced redox imbalance promotes vesiculation of irreversibly oxidized GAPDH, as determined through switch-tag redox proteomics.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/12/e32/1396247/e32.pdf

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