Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI-Reference-Cited by-同舟云学术

Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI

Published:2017-02-23 Issue:8 Volume:129 Page:1008-1020
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Agarwal Puneet¹,Zhang Bin²,Ho Yinwei²,Cook Amy²,Li Ling²,Mikhail Fady M.³,Wang Youzhen⁴,McLaughlin Margaret E.⁴,Bhatia Ravi¹

Affiliation:

1. Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL;

2. Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA;

3. Department of Genetics, University of Alabama at Birmingham, Birmingham, AL; and

4. Oncology Disease Area, Novartis Institute of Biomedical Research, Cambridge, MA

Abstract

Key Points CML progenitor cells demonstrate enhanced sensitivity to Wnt stimulation, related to increased FZD4 receptor expression. Wnt inhibition by a Porcupine acyl transferase inhibitor enhances CML stem/progenitor cell targeting in combination with tyrosine kinase inhibition.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/8/1008/1465434/blood714089.pdf

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