Myeloma cell–derived Runx2 promotes myeloma progression in bone

Author:

Trotter Timothy N.1,Li Mei1,Pan Qianying12,Peker Deniz1,Rowan Patrick D.1,Li Juan2,Zhan Fenghuang3,Suva Larry J.4,Javed Amjad56,Yang Yang15

Affiliation:

1. Department of Pathology, University of Alabama at Birmingham, Birmingham, AL;

2. Department of Hematology, The First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China;

3. Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa;

4. Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, AR; and

5. Comprehensive Cancer Center and the Center for Metabolic Bone Disease, and

6. Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL

Abstract

Key Points Myeloma cell–derived Runx2 promotes myeloma progression. High levels of Runx2 expression are associated with a high-risk myeloma population.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference70 articles.

1. Heparanase promotes the spontaneous metastasis of myeloma cells to bone.;Yang;Blood,2005

2. Pathogenesis of myeloma.;Anderson;Annu Rev Pathol,2011

3. Curing myeloma at last: defining criteria and providing the evidence.;Barlogie;Blood,2014

4. Myeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells.;Noll;Haematologica,2014

5. Pathophysiological underpinnings of multiple myeloma progression.;Jagannath;J Manag Care Pharm,2008

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