MicroRNA-155–deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation-Reference-Cited by-同舟云学术

MicroRNA-155–deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation

Published:2015-07-02 Issue:1 Volume:126 Page:103-112
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chen Sophia¹,Smith Benjamin A. H.¹^ORCID,Iype Joseena¹,Prestipino Alessandro¹,Pfeifer Dietmar¹,Grundmann Sebastian²,Schmitt-Graeff Annette³,Idzko Marco⁴,Beck Yvonne¹,Prinz Gabriele¹,Finke Jürgen¹,Duyster Justus¹,Zeiser Robert¹⁵

Affiliation:

1. Department of Hematology and Oncology, Freiburg University Medical Center,

2. Department of Cardiology and Angiology I, Heart Center, University of Freiburg,

3. Department of Pathology,

4. Department of Pneumology, Freiburg University Medical Center, and

5. Centre for Biological Signalling Studies BIOSS, Albert-Ludwigs-University, Freiburg, Germany

Abstract

Key Points GVHD induction is dependent on functional miR-155 in DCs of the allo-HCT recipient. MiR-155 deficiency reduces ATP-mediated cell migration, ERK and inflammasome activation, and IL-1β production of DCs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/1/103/1345638/103.pdf

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