Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation-Reference-Cited by-同舟云学术

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

Published:2015-04-16 Issue:16 Volume:125 Page:2530-2543
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Alinari Lapo¹,Mahasenan Kiran V.²,Yan Fengting¹,Karkhanis Vrajesh³,Chung Ji-Hyun³,Smith Emily M.¹,Quinion Carl¹,Smith Porsha L.¹,Kim Lisa¹,Patton John T.¹,Lapalombella Rosa¹,Yu Bo¹,Wu Yun¹,Roy Satavisha³,De Leo Alessandra⁴,Pileri Stefano⁵,Agostinelli Claudio⁵,Ayers Leona⁶,Bradner James E.⁷,Chen-Kiang Selina⁸,Elemento Olivier⁹,Motiwala Tasneem³,Majumder Sarmila³,Byrd John C.¹²,Jacob Samson³,Sif Said¹⁰,Li Chenglong²,Baiocchi Robert A.¹

Affiliation:

1. Division of Hematology, Department of Internal Medicine,

2. Division of Medicinal Chemistry and Pharmacognosy, and

3. Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH;

4. Department of Public Health and Infectious Diseases, University La Sapienza, Rome, Italy;

5. Hematopathology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy;

6. Department of Pathology, The Ohio State University, Columbus, OH;

7. Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

8. Department of Pathology and Laboratory Medicine, and

9. Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY; and

10. Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar

Abstract

Key PointsEBV infection leads to PRMT5 overexpression and global epigenetic changes that are essential to drive B-lymphocyte transformation. Highly selective PRMT5 inhibitors represent a novel, first-in-class drug that restores critical regulatory checkpoints in lymphoma cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/16/2530/1385112/2530.pdf

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