Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A-Reference-Cited by-同舟云学术

Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A

Published:2015-08-06 Issue:6 Volume:126 Page:766-778
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Li Yanmei¹,Shi Yonghong¹,McCaw Lindsay¹,Li You-Jun¹²,Zhu Fang³⁴,Gorczynski Reg³⁴,Duncan Gordon S.⁵,Yang Burton¹⁶,Ben-David Yaacov⁷,Spaner David E.¹³⁸⁹

Affiliation:

1. Biology Platform, Sunnybrook Research Institute, Toronto, Canada;

2. Department of Anatomy, Norman Bethune College of Medicine, Jilin University, Changchun, China;

3. Department of Immunology, University of Toronto, Toronto, Canada;

4. Transplant Research Division, Toronto General Hospital, Toronto, Canada;

5. Campbell Family Institute for Cancer Research, The Princess Margaret Cancer Centre, Toronto, Canada;

6. Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, Canada;

7. Division of Biology, The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, China; and

8. Department of Medicine and

9. Department of Medical Biophysics, University of Toronto, Toronto, Canada

Abstract

Key Points IL-6 from splenic stromal cells prevents CLL cells from responding strongly to TLR ligands. IL-6–signaling inhibitors enhance TLR-mediated responses of CLL cells in vitro and in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/6/766/1391274/766.pdf

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